Neocin-PG Drops

Pronunciation: gram-i-SYE-din/NEE-oh-MYE-sin/POL-ee-MIX-in
Generic Name: Gramicidin/Neomycin/Polymyxin
Brand Name: Examples include Neocin-PG and Neosporin

Neocin-PG Drops are used for:

Treating eye infections caused by certain bacteria.

Neocin-PG Drops are an antibiotic. It works by killing sensitive bacteria on the eye.

Do NOT use Neocin-PG Drops if:

• you are allergic to any ingredient in Neocin-PG Drops or to other aminoglycosides (eg, tobramycin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Neocin-PG Drops:

Some medical conditions may interact with Neocin-PG Drops. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Neocin-PG Drops. Because little, if any, of Neocin-PG Drops are absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Neocin-PG Drops may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Neocin-PG Drops:

Use Neocin-PG Drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• To use Neocin-PG Drops in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.


• To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.


• Do not wear contact lenses while you are using Neocin-PG Drops. Take care of your contact lenses as directed by the manufacturer. Check with your doctor before you use them.


• To prevent reinfection, wash your hands before and after using Neocin-PG Drops.


• To clear up your infection completely, use Neocin-PG Drops for the full course of treatment. Keep using it even if you feel better in a few days. Do not miss any doses.


• If you miss a dose of Neocin-PG Drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Neocin-PG Drops.

Important safety information:

• Neocin-PG Drops only works against bacteria; it does not treat fungal or viral infections.


• Be sure to use Neocin-PG Drops for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.


• Long-term or repeated use of Neocin-PG Drops may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.


• If your symptoms do not get better within a few days or if they get worse, check with your doctor.


• Do not use Neocin-PG Drops for future eye problems unless directed by your doctor.


• Neocin-PG Drops should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Neocin-PG Drops while you are pregnant. It is not known if Neocin-PG Drops are found in breast milk. If you are or will be breast-feeding while you use Neocin-PG Drops, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Neocin-PG Drops:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild burning, irritation, or stinging.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in vision; continued redness, burning, swelling, or itching; eye discharge; eye pain; secondary infection.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Neocin-PG side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Neocin-PG Drops:

Store Neocin-PG Drops at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Keep Neocin-PG Drops out of the reach of children and away from pets.

General information:

• If you have any questions about Neocin-PG Drops, please talk with your doctor, pharmacist, or other health care provider.


• Neocin-PG Drops are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Neocin-PG Drops. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Neocin-PG resources

• Neocin-PG Side Effects (in more detail)
• Neocin-PG Use in Pregnancy & Breastfeeding
• Neocin-PG Support Group
• 0 Reviews for Neocin-PG - Add your own review/rating

Compare Neocin-PG with other medications

• Conjunctivitis, Bacterial

Guanfacine Extended-Release Tablets

Pronunciation: GWAHN-fa-seen
Generic Name: Guanfacine
Brand Name: Intuniv

Guanfacine Extended-Release Tablets are used for:

Treating attention deficit hyperactivity disorder (ADHD).

Guanfacine Extended-Release Tablets are an alpha agonist. Exactly how Guanfacine Extended-Release Tablets works to treat ADHD is not known.

Do NOT use Guanfacine Extended-Release Tablets if:

• you are allergic to any ingredient in Guanfacine Extended-Release Tablets


• you are taking another medicine that contains guanfacine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Guanfacine Extended-Release Tablets:

Some medical conditions may interact with Guanfacine Extended-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of low blood pressure, dizziness when you stand up, heart problems (eg, heart block, slow or irregular heartbeat), or fainting


• if you have liver or kidney problems


• if you are dehydrated or will be exposed to high temperatures


• if you are taking medicine for high blood pressure

Some MEDICINES MAY INTERACT with Guanfacine Extended-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Tizanidine or medicine for high blood pressure because the risk of low blood pressure or fainting may be increased


• Ketoconazole because it may increase the risk of Guanfacine Extended-Release Tablets's side effects


• Rifampin because it may decrease Guanfacine Extended-Release Tablets's effectiveness


• Barbiturates (eg, phenobarbital), benzodiazepines (eg, diazepam), phenothiazines (eg, chlorpromazine), or valproic acid because the risk of their side effects may be increased by Guanfacine Extended-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Guanfacine Extended-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Guanfacine Extended-Release Tablets:

Use Guanfacine Extended-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Guanfacine Extended-Release Tablets. Talk to your pharmacist if you have questions about this information.


• Take Guanfacine Extended-Release Tablets by mouth with or without food. Do not take it with a high-fat meal.


• Take Guanfacine Extended-Release Tablets with water, milk, or another liquid.


• Swallow Guanfacine Extended-Release Tablets whole. Do not break, crush, or chew before swallowing.


• If you are switching to Guanfacine Extended-Release Tablets from immediate-release guanfacine, talk with your doctor about how you should stop taking the immediate-release tablets and start taking Guanfacine Extended-Release Tablets.


• Do not suddenly stop taking Guanfacine Extended-Release Tablets. You may have an increased risk of side effects. If you need to stop Guanfacine Extended-Release Tablets, your doctor will gradually lower your dose.


• If you miss a dose of Guanfacine Extended-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss more than 1 dose, contact your doctor.

Ask your health care provider any questions you may have about how to use Guanfacine Extended-Release Tablets.

Important safety information:

• Guanfacine Extended-Release Tablets may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Guanfacine Extended-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Guanfacine Extended-Release Tablets may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Do not drink alcohol while you are taking Guanfacine Extended-Release Tablets.


• Talk with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Guanfacine Extended-Release Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Do NOT take more than the recommended dose without checking with your doctor.


• Do not become overheated or dehydrated in hot weather or while you are being active; the risk of low blood pressure or fainting may be increased.


• Lab tests, including heart rate and blood pressure, may be performed while you use Guanfacine Extended-Release Tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Guanfacine Extended-Release Tablets should be used with extreme caution in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Guanfacine Extended-Release Tablets while you are pregnant. It is not known if Guanfacine Extended-Release Tablets are found in breast milk. If you are or will be breast-feeding while you use Guanfacine Extended-Release Tablets, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Guanfacine Extended-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; decreased appetite; dizziness; drowsiness; dry mouth; headache; irritability; nausea; sluggishness; stomach pain; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; severe or persistent dizziness, drowsiness, or weakness; slow or irregular heartbeat.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Guanfacine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include pinpoint pupils; severe or persistent dizziness, drowsiness, or sluggishness; slow heartbeat.

Proper storage of Guanfacine Extended-Release Tablets:

Store Guanfacine Extended-Release Tablets at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Guanfacine Extended-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Guanfacine Extended-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.


• Guanfacine Extended-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Guanfacine Extended-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Guanfacine resources

• Guanfacine Side Effects (in more detail)
• Guanfacine Dosage
• Guanfacine Use in Pregnancy & Breastfeeding
• Drug Images
• Guanfacine Drug Interactions
• Guanfacine Support Group
• 53 Reviews for Guanfacine - Add your own review/rating

Compare Guanfacine with other medications

• ADHD
• High Blood Pressure

Ginkgo Biloba Controlled-Release Tablets

Pronunciation: Not applicable.
Generic Name: Ginkgo Biloba
Brand Name: Generics only. No brands available.

Ginkgo Biloba Controlled-Release Tablets are used for:

Circulation and memory loss due to brain conditions such as stroke, Alzheimer disease, and dementia. It may also have other uses. Check with your pharmacist for more details regarding the particular brand you use.

Ginkgo Biloba Controlled-Release Tablets are an herbal product. It works by increasing blood flow to the brain.

Do NOT use Ginkgo Biloba Controlled-Release Tablets if:

• you are allergic to any ingredient in Ginkgo Biloba Controlled-Release Tablets

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ginkgo Biloba Controlled-Release Tablets:

Some medical conditions may interact with Ginkgo Biloba Controlled-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of blood disorders or bleeding conditions

Some MEDICINES MAY INTERACT with Ginkgo Biloba Controlled-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Nonsteroidal anti-inflammatory drugs (NSAIDs; eg, aspirin, ibuprofen) or warfarin because the risk of serious bleeding may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ginkgo Biloba Controlled-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ginkgo Biloba Controlled-Release Tablets:

Use Ginkgo Biloba Controlled-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Dosing depends on the use and the source of the product.


• Use as directed on the package, unless instructed otherwise by your doctor.


• Swallow whole. Do not break, crush, or chew before swallowing.


• If you miss taking a dose of Ginkgo Biloba Controlled-Release Tablets for 1 or more days, there is no cause for concern. If your doctor recommended that you take it, try to remember your dose every day.

Ask your health care provider any questions you may have about how to use Ginkgo Biloba Controlled-Release Tablets.

Important safety information:

• Ginkgo Biloba Controlled-Release Tablets may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Ginkgo Biloba Controlled-Release Tablets. Using Ginkgo Biloba Controlled-Release Tablets alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.


• If you are using this product for brain conditions, consult your doctor or pharmacist. A medical evaluation or prescription medicine may be needed to treat your condition.


• Do not exceed the recommended dose or take this product for longer than 3 months without checking with your doctor.


• Check with your doctor before you begin taking any new medicine, either prescription or over-the-counter, including any medicine that contains aspirin or other NSAIDs (eg, ibuprofen).


• This product has not been approved by the Food and Drug Administration (FDA) as safe and effective for any medical condition. The long-term safety of herbal products is not known. Before using any alternative medicine, talk with your doctor or pharmacist.


• This product is not recommended for use in CHILDREN.


• PREGNANCY and BREAST-FEEDING: Use of Ginkgo Biloba Controlled-Release Tablets are not recommended if you are pregnant or breast-feeding. If you plan on becoming pregnant, discuss with your doctor the risks of using this product during pregnancy.

Possible side effects of Ginkgo Biloba Controlled-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; gas; headache; nausea; stomach upset.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; pounding in the chest; skin redness; trouble speaking; unusual bruising or bleeding; weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Ginkgo Biloba side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include seizures.

Proper storage of Ginkgo Biloba Controlled-Release Tablets:

Store at room temperature away from heat, moisture, and light unless otherwise directed on the package label. Do not store in the bathroom. Most herbal products are not in childproof containers. Keep Ginkgo Biloba Controlled-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Ginkgo Biloba Controlled-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.


• Ginkgo Biloba Controlled-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Ginkgo Biloba Controlled-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Ginkgo Biloba resources

• Ginkgo Biloba Side Effects (in more detail)
• Ginkgo Biloba Drug Interactions
• Ginkgo Biloba Support Group
• 0 Reviews for Ginkgo Biloba - Add your own review/rating

Compare Ginkgo Biloba with other medications

• Herbal Supplementation

Androderm

Generic Name: testosterone (Transdermal route)

tes-TOS-ter-one

Commonly used brand name(s)

In the U.S.

• Androderm

In Canada

• Androplex

Available Dosage Forms:

• Patch, Extended Release

Therapeutic Class: Endocrine-Metabolic Agent

Pharmacologic Class: Androgen

Uses For Androderm

Testosterone transdermal patch is used for the treatment of males whose bodies do not make enough natural testosterone, a condition called hypogonadism. Testosterone is a male hormone responsible for the growth and development of the male sex organs and maintenance of secondary sex characteristics.

This medicine is available only with your doctor's prescription.

Before Using Androderm

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of testosterone transdermal patch in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies have not been performed on the relationship of age to the effects of testosterone transdermal patch in the geriatric population. However, elderly patients may be at an increased risk for developing prostate problems, including prostate cancer, which may require caution in patients receiving testosterone transdermal patch.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Anisindione


• Bupropion


• Dicumarol


• Paclitaxel


• Paclitaxel Protein-Bound


• Phenprocoumon


• Warfarin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Licorice

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood disorder (e.g., polycythemia)—May increase risk for thromboembolic diseases.

• Breast cancer (males) or


• Prostate cancer, known or suspected—Should not be used in patients with these conditions.

• Drug abuse or dependence, history of or


• Enlarged prostate or


• Hypercalcemia (high calcium in the blood) or


• Problems in passing urine or


• Sleep apnea (breathing problem)—Use with caution. May make these conditions worse.

• Heart disease or


• Kidney disease or


• Liver disease—Use with caution. Testosterone may cause edema (fluid retention) in patients with these conditions.

• Lung disease or


• Obesity—May increase risk for sleep apnea.

Proper Use of testosterone

This section provides information on the proper use of a number of products that contain testosterone. It may not be specific to Androderm. Please read with care.

This medicine comes with a Medication Guide and patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

Testosterone skin patch comes in four different doses and different patch sizes. Ask your doctor which is the right one for you.

Make sure that you wash your hands with soap and water before and after applying the patch.

For patients using the patch:

• After opening the pouch that contains the patch, apply the patch immediately.


• Apply the patch to a clean, dry area of the skin on your back, abdomen, thighs, or upper arm. Do not put the patch over burns, cuts, or irritated skin. Avoid putting the patch on oily or sweaty skin, or on areas covered with hair, since the patch may not stick tightly to these areas.


• Do not apply the patch to your scrotum or genital area. Avoid applying this medicine to a bony area (such as your shoulder) or to an area that might be under pressure for a long time (such as the back of your leg when you are sitting).


• The patch can be worn during sexual intercourse, or while taking a shower or bath. Wait for at least 3 hours after applying the medicine before you shower, swim, or wash the application site. However, heavy exercise and sweating may cause the patch to fall off.


• When replacing an old patch, make sure that you apply the new patch on a different spot. Do not put another patch back on the same spot for at least 7 days.


• Do not apply any type of ointment product on your skin before you put on the patch.


• If a patch comes off, just put it back on the same spot. If the patch will not stick and you have been wearing it for fewer than 12 hours, put on a new patch. Then stay on your regular schedule and replace it with a fresh patch at your next regular time. If you have already been wearing the patch for more than 12 hours, do not put on a new patch. Wait to put on a new patch at your next regular time. Do not use extra patches to make up for the one that came off.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For transdermal dosage form (patch):
  
  • For hormone replacement:
    
    • Adults—At first, one 4-milligram (mg) or 5-mg, or two 2.5-mg patches applied nightly for 24 hours. Your doctor may adjust your dose as needed.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  
  • For non-virilized patients:
    
    • Adults—One 2.5-milligram patch applied nightly.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you forget to wear or change a patch, put one on as soon as you can. If it is almost time to put on your next patch, wait until then to apply a new patch and skip the one you missed. Do not apply extra patches to make up for a missed dose.

Storage

Store the patches at room temperature in a closed container, away from heat, moisture, and direct light.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Androderm

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and check for any problems or unwanted effects that may be caused by this medicine. Blood tests will be needed to check for unwanted effects.

This medicine should not be used by women. Testosterone may cause birth defects if a pregnant woman comes in contact with the patch or medicine. Make sure your doctor knows if your sexual partner is pregnant. If a pregnancy occurs while you are using this medicine, tell your doctor right away.

If a woman comes in contact with the patch, wash the skin area right away with soap and water to remove all the medicine. If the patch sticks to a woman, remove the patch right away and wash her skin thoroughly with soap and water.

If your female partner starts to have male-like changes such as unusual hair growth or increased acne, check with your doctor.

This medicine may increase the risk of prostate cancer, especially in older men. Make sure your doctor knows if you have prostate cancer, or if anyone in your family has prostate cancer.

In some cases, this medicine may decrease the amount of sperm men make and affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.

Tell your doctor if you experience too frequent erection of the penis, nausea, vomiting, yellowing of your skin or the whites of your eyes, or swelling of the ankle.

This medicine may cause swelling of the breasts (gynecomastia) and breast pain in some patients. If you have questions about this, talk to your doctor.

This medicine may cause changes in the level of cholesterol and fats in your blood. If this condition occurs, your doctor may give you a medicine to adjust the cholesterol and fats. Talk to your doctor if you have concerns.

This medicine contains aluminum that may cause skin burns at the patch site if you have a procedure called a magnetic resonance imaging (MRI) scan while you are wearing the patch. You must remove the patch before your MRI to prevent skin burns.

Check with your doctor immediately if mild, burn-like skin blisters, redness, itching, or swelling occurs at the site of application during or after treatment.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Androderm Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Skin itching, blistering, or redness at the application site

Less common

• Blistering, burning, crusting, dryness, or flaking of the skin


• bloody or black, tarry stools


• burning feeling at the application site


• constipation


• difficult urination


• hardening or thickening of the skin under patch


• itching, scaling, severe redness, soreness, or swelling of the skin


• pelvic pain


• severe stomach pain


• vomiting of blood or material that looks like coffee grounds

Rare

• Bladder pain


• bloody or cloudy urine


• blurred vision


• difficult, burning, or painful urination


• dizziness


• frequent urge to urinate


• headache


• lower back or side pain


• nervousness


• pounding in the ears


• slow or fast heartbeat


• testicular problems

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Discouragement


• feeling sad or empty


• irritability


• lack of appetite


• loss of interest or pleasure


• rash


• tiredness


• trouble concentrating


• trouble sleeping

Rare

• Accelerated growth


• blemishes on the skin


• body pain


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• cold hands and feet


• contamination of the application site


• decreased interest in sexual intercourse


• fear


• feeling of constant movement of self or surroundings


• inability to have or keep an erection


• increased appetite


• lightheadedness


• loss in sexual ability, desire, drive, or performance


• loss of bladder control


• mood or mental changes


• pimples


• sensation of spinning


• thinking abnormalities


• weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Androderm side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Androderm resources

• Androderm Side Effects (in more detail)
• Androderm Use in Pregnancy & Breastfeeding
• Androderm Drug Interactions
• Androderm Support Group
• 9 Reviews for Androderm - Add your own review/rating

• Androderm Patch MedFacts Consumer Leaflet (Wolters Kluwer)


• Androderm Prescribing Information (FDA)


• Testosterone Monograph (AHFS DI)


• Testosterone Prescribing Information (FDA)


• Testosterone Professional Patient Advice (Wolters Kluwer)


• AndroGel Prescribing Information (FDA)


• AndroGel Gel MedFacts Consumer Leaflet (Wolters Kluwer)


• Androgel Consumer Overview


• Axiron Prescribing Information (FDA)


• Axiron Consumer Overview


• Axiron Solution MedFacts Consumer Leaflet (Wolters Kluwer)


• Delatestryl MedFacts Consumer Leaflet (Wolters Kluwer)


• Delatestryl Prescribing Information (FDA)


• Depo-Testosterone Prescribing Information (FDA)


• Depo-Testosterone MedFacts Consumer Leaflet (Wolters Kluwer)


• Fortesta Gel MedFacts Consumer Leaflet (Wolters Kluwer)


• Fortesta Consumer Overview


• Striant Prescribing Information (FDA)


• Striant Consumer Overview


• Striant MedFacts Consumer Leaflet (Wolters Kluwer)


• Testim Gel MedFacts Consumer Leaflet (Wolters Kluwer)


• Testim Prescribing Information (FDA)


• Testosterone Cypionate Prescribing Information (FDA)


• Testosterone Enanthate Prescribing Information (FDA)

Compare Androderm with other medications

• Hypogonadism, Male

psorcon

diflorasone diacetate

Dosage Form: Cream, 0.05%

For Dermatological Use Only – Not for Ophthalmic Use.

psorcon Description

psorcon® (diflorasone diacetate cream) contains the active compound diflorasone diacetate, a synthetic corticosteroid for topical dermatological use.

Chemically, diflorasone diacetate is 6α,9α-difluoro-11β,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17,21 diacetate, with the empirical formula C26H32F2O7, a molecular weight of 494.5, and the following structural formula:

Each gram of psorcon Cream contains 0.5 mg diflorasone diacetate in a cream base consisting of purified water USP, propylene glycol USP, mineral oil (and) lanolin alcohol, glyceryl stearate SE (nonionic), isopropyl myristate NF, polysorbate 60 NF, sorbitan monostearate NF, polyoxyl 40 stearate NF, cetyl alcohol NF, monobasic sodium phosphate USP, vegetable oil, monoglyceride citrate, BHT and citric acid.

psorcon - Clinical Pharmacology

Like other topical corticosteroids, diflorasone diacetate has anti-inflammatory, anti-pruritic, and vasoconstrictive actions. The mechanism of the anti-inflammatory activity of the topical corticosteroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

Pharmacokinetics

The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle and the integrity of the epidermal barrier. Occlusive dressings with hydrocortisone for up to 24 hours have not been demonstrated to increase penetration; however, occlusion of hydrocortisone for 96 hours markedly enhances penetration. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin may increase percutaneous absorption. Studies performed with psorcon Cream indicate that it is in the high range of potency as compared with other topical corticosteroids.

INDICATION AND USAGE

psorcon (diflorasone diacetate cream), 0.05% is a high potency corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Contraindications

psorcon (diflorasone diacetate cream) is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.

Precautions

General

Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment. Manifestations of Cushing's syndrome, hyperglycemia, and glucosuria can also be produced in some patients by systemic absorption of topical corticosteroids while on treatment.

Patients receiving a large dose of a higher potency topical steroid applied to a large surface area or under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression. This may be done by using the ACTH-stimulation, A.M. plasma cortisol, and urinary free-cortisol tests.

This product has a greater ability to produce adrenal suppression than does psorcon (diflorasone diacetate) Ointment, 0.05%. At 30 g per day (applied as 15 g twice daily) psorcon Cream, 0.05% was shown to cause inhibition of the HPA axis in one of two patients following application for one week to psoriatic skin. At 15 g per day (applied as 7.5 g twice daily) psorcon Cream was shown to cause mild inhibition of the HPA axis in one of five patients following application for one week to diseased skin (psoriasis or atopic dermatitis). These effects were reversible upon discontinuation of treatment. By comparison, psorcon (diflorasone diacetate) Ointment, 0.05% did not produce significant HPA axis suppression when used in divided doses at 30 g per day for one week in patients with psoriasis or atopic dermatitis.

If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent corticosteroid. Recovery of HPA axis function is generally prompt and complete upon discontinuation of topical corticosteroids. Infrequently, signs and symptoms of glucocorticosteroid insufficiency may occur, requiring supplemental systemic corticosteroids. For information on systemic supplementation, see prescribing information for those products.

Pediatric patients may be more susceptible to systemic toxicity from equivalent doses due to their larger skin surface to body mass ratios (see PRECAUTIONS: Pediatric Use).

If irritation develops, psorcon (diflorasone diacetate cream) should be discontinued and appropriate therapy instituted. Allergic contact dermatitis with corticosteroids is usually diagnosed by observing failure to heal rather than noting a clinical exacerbation as with most topical products not containing corticosteroids. Such an observation should be corroborated with appropriate diagnostic patch testing.

If concomitant skin infections are present or develop, an appropriate antifungal or antibacterial agent should be used. If a favorable response does not occur promptly, use of psorcon (diflorasone diacetate cream) should be discontinued until the infection has been adequately controlled.

psorcon (diflorasone diacetate cream) should not be used in the treatment of rosacea or perioral dermatitis, and it should not be used on the face, groin, or axillae.

Information for Patients

Patients using topical corticosteroids should receive the following information and instructions:

1. The medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes.


2. The medication should not be used for any disorder other than that for which it was prescribed.


3. The treated skin area should not be bandaged or otherwise covered or wrapped so as to be occlusive unless directed by the physician.


4. Patients should report to their physician any signs of local adverse reactions.

Laboratory Tests

The following tests may be helpful in evaluating patients for HPA axis suppression: ACTH-stimulation test; A.M. plasma-cortisol test; Urinary free-cortisol test.

Carcinogenesis, Mutagenesis and Impairment of Fertility

Long-term animal studies have not been performed to evaluate the carcinogenic potential of diflorasone diacetate.

Diflorasone diacetate was not found to be mutagenic in a micronucleus test in rats at dosages of 2400 mg/kg.

Studies in the rat following topical administration at doses up to 0.5 mg/kg revealed no effects on fertility.

Pregnancy

Teratogenic effects

Pregnancy Category C. Corticosteroids have been shown to be teratogenic in laboratory animals when administered systemically at relatively low dosage levels. Some corticosteroids have been shown to be teratogenic after dermal application to laboratory animals.

Diflorasone diacetate has been shown to be teratogenic (cleft palate) in rats when applied topically at a dose of approximately 0.001 mg/kg/day to the shaven thorax of pregnant animals. This is approximately 0.3 times the human topical dose of psorcon (diflorasone diacetate cream). When pregnant rats were treated topically with approximately 0.5 mg/kg/day, uterine deaths were higher in the treated animals than in control animals.

In rabbits, cleft palate was seen when diflorasone diacetate was applied in topical doses as low as 20 mg/kg/day. In addition, fetal weight was depressed and litter sizes were smaller.

There are no adequate and well-controlled studies of the teratogenic potential of diflorasone diacetate in pregnant women. psorcon Cream should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Mothers

Systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Because many drugs are excreted in human milk, caution should be exercised when psorcon (diflorasone diacetate cream) is administered to a nursing woman.

Pediatric Use

Safety and effectiveness of psorcon (diflorasone diacetate cream) in pediatric patients have not been established. Because of a higher ratio of skin surface area to body mass, pediatric patients are at a greater risk than adults of HPA-axis suppression when they are treated with topical corticosteroids. They are, therefore, also at greater risk of glucocorticosteroid insufficiency after withdrawal of treatment and of Cushing's syndrome while on treatment. Adverse effects including striae have been reported with inappropriate use of topical corticosteroids in pediatric patients.

HPA axis suppression, Cushing's syndrome, and intracranial hypertension have been reported in pediatric patients receiving topical corticosteroids. Manifestations of adrenal suppression in pediatric patients include linear growth retardation, delayed weight gain, low plasma cortisol levels, and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include bulging fontanelles, headaches, and bilateral papilledema.

Adverse Reactions

The following local adverse reactions have been reported infrequently with other topical corticosteroids, and they may occur more frequently with the use of occlusive dressings, especially with higher potency corticosteroids. These reactions are listed in an approximate decreasing order of occurrence: burning, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infections, skin atrophy, striae, and miliaria.

Overdosage

Topically applied psorcon (diflorasone diacetate cream) can be absorbed in sufficient amounts to produce systemic effects (see PRECAUTIONS).

psorcon Dosage and Administration

psorcon (diflorasone diacetate cream) should be applied to the affected area twice daily.

How is psorcon Supplied

psorcon Cream 0.05% is available in the following size tubes:

60 gram NDC 0066-0069-60

Store at or below 25° C (77° F).

Prescribing Information as of March 2002.

Manufactured by:

Pharmacia & Upjohn Company

Kalamazoo, MI 49001 USA

For Dermik Laboratories, Inc.

Berwyn, PA USA 19312

PSORCON  diflorasone diacetate  cream

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0066-0069 Route of Administration TOPICAL DEA Schedule

INGREDIENTS Name (Active Moiety) Type Strength diflorasone diacetate (diflorasone) Active 0.5 MILLIGRAM  In 60 GRAM water Inactive   propylene glycol Inactive   mineral oil Inactive   lanolin alcohol Inactive   glyceryl stearate SE (nonionic) Inactive   isopropyl myristate Inactive   polysorbate 60 Inactive   sorbitan monostearate Inactive   polyoxyl 40 stearate Inactive   cetyl alcohol Inactive   monobasic sodium phosphate Inactive   vegetable oil Inactive   monoglyceride citrate Inactive   BHT Inactive   citric acid Inactive

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 0066-0069-60 60 g (GRAM) In 1 TUBE None

Revised: 01/2009Dermik Laboratories, Inc.

More psorcon resources

• Psorcon Side Effects (in more detail)
• Psorcon Use in Pregnancy & Breastfeeding
• Psorcon Drug Interactions
• Psorcon Support Group
• 0 Reviews for Psorcon - Add your own review/rating

• ApexiCon Concise Consumer Information (Cerner Multum)


• Apexicon Advanced Consumer (Micromedex) - Includes Dosage Information


• Apexicon Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Psorcon Monograph (AHFS DI)

Compare psorcon with other medications

• Atopic Dermatitis
• Eczema
• Psoriasis
• Skin Rash
• Urticaria

Levsin

Pronunciation: HYE-oh-SYE-a-meen
Generic Name: Hyoscyamine
Brand Name: Levsin

Levsin is used for:

Treating certain stomach or bowel problems (eg, ulcers, spasms or cramping, irritable bowel syndrome, symptoms of colic), certain bladder problems (eg, spastic bladder, cystitis), and excessive secretions caused by inflammation of the pancreas, and for aiding in certain medical procedures or surgery. It may also be used for other conditions as determined by your doctor.

Levsin is an anticholinergic agent. It works by decreasing the motion of the stomach and intestines and the secretion of stomach fluids, including acid.

Do NOT use Levsin if:

• you are allergic to any ingredient in Levsin


• you have severe esophagus problems (eg, irritation, narrowing); a blockage of the stomach, bowel, or bladder; bowel motility problems; or severe bowel problems (eg, severe ulcerative colitis, toxic megacolon)


• you have glaucoma, myasthenia gravis, or heart problems caused by severe bleeding

Contact your doctor or health care provider right away if any of these apply to you.

Before using Levsin:

Some medical conditions may interact with Levsin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have nerve problems, prostate problems, esophagus problems (eg, reflux), stomach or bowel problems, heart or blood vessel problems (eg, fast or irregular heartbeat, heart failure, coronary heart disease), hiatal hernia, kidney problems, an overactive thyroid, high blood pressure, urinary problems, paralysis, or brain damage, or if you are at risk for glaucoma


• if you have diarrhea or fever, have been very ill, or are in poor health

Some MEDICINES MAY INTERACT with Levsin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Amantadine, antihistamines (eg, diphenhydramine), haloperidol, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), other anticholinergics (eg, scopolamine), phenothiazines (eg, thioridazine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Levsin's side effects


• Narcotic pain medicines (eg, codeine) or potassium chloride because the risk of their side effects may be increased by Levsin


• Ketoconazole or metoclopramide because their effectiveness may be decreased by Levsin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Levsin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Levsin:

Use Levsin as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

• Levsin is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Levsin at home, a health care provider will teach you how to use it. Be sure you understand how to use Levsin. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.


• Do not use Levsin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.


• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.


• If you miss a dose of Levsin, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Levsin.

Important safety information:

• Levsin may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Levsin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Levsin; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Do not become overheated or dehydrated in hot weather or while you are being active; heatstroke may occur.


• Drink plenty of fluids, maintain good oral hygiene, and suck on sugarless hard candy to relieve dry mouth.


• Proper dental care is important while you are taking Levsin. Brush and floss your teeth and visit the dentist regularly.


• Levsin may make your eyes more sensitive to sunlight. It may help to wear sunglasses.


• Tell your doctor or dentist that you take Levsin before you receive any medical or dental care, emergency care, or surgery.


• Use Levsin with caution in the ELDERLY; they may be more sensitive to its effects, especially constipation, trouble urinating, dry mouth, drowsiness, agitation, confusion, excitability, or memory problems.


• Caution is advised when using Levsin in CHILDREN; they may be more sensitive to its effects, including excitability.


• Levsin should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Levsin while you are pregnant. Levsin is found in breast milk. Do not breast-feed while taking Levsin.

Possible side effects of Levsin:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloated feeling; blurred vision; constipation; decreased sweating; dizziness; drowsiness; dry mouth; enlarged pupils; excitability; headache; nausea; nervousness; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; behavior changes; confusion; decreased sexual ability; diarrhea; difficulty focusing eyes; disorientation; exaggerated sense of well-being; fast or irregular heartbeat; hallucinations; loss of consciousness; loss of coordination; memory loss; mental or mood changes; severe or persistent trouble sleeping; speech changes; taste changes or loss; trouble urinating; unusual tiredness or weakness; vision changes; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Levsin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; difficulty breathing; difficulty swallowing; disorientation; dizziness; dry mouth; dry skin; enlarged pupils; excessive thirst; excitability; headache; muscle weakness; nausea; rapid heartbeat with weak pulse; seizures; vomiting.

Proper storage of Levsin:

Levsin is usually handled and stored by a health care provider. If you are using Levsin at home, store Levsin as directed by your pharmacist or health care provider. Keep Levsin out of the reach of children and away from pets.

General information:

• If you have any questions about Levsin, please talk with your doctor, pharmacist, or other health care provider.


• Levsin is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Levsin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Levsin resources

• Levsin Side Effects (in more detail)
• Levsin Use in Pregnancy & Breastfeeding
• Drug Images
• Levsin Drug Interactions
• Levsin Support Group
• 1 Review for Levsin - Add your own review/rating

• Levsin Prescribing Information (FDA)


• Levsin Concise Consumer Information (Cerner Multum)


• Hyoscyamine Monograph (AHFS DI)


• HyoMax Prescribing Information (FDA)


• Hyosyne Prescribing Information (FDA)

Compare Levsin with other medications

• Anesthesia
• Crohn's Disease
• Endoscopy or Radiology Premedication
• Irritable Bowel Syndrome
• Urinary Incontinence

Epoetin Alfa

Pronunciation: e-POE-e-tin AL-fa
Generic Name: Epoetin Alfa
Brand Name: Examples include Epogen and Procrit

Clinical studies have shown Epoetin Alfa to increase the risk of serious side effects (eg, blood clots, stroke, heart attack, heart failure) and death in some cases. It has also been shown to shorten the overall survival and/or increase the risk of tumor growth or recurrence in patients with certain types of cancer. Talk with your doctor about the risks and benefits of using Epoetin Alfa. Do not use more than the recommended dose without checking with your doctor.

Epoetin Alfa is used for:

Treating anemia in certain patients with chronic kidney disease, anemia caused by chemotherapy in certain cancer patients, or anemia caused by taking zidovudine in certain HIV patients. It is also used to reduce the need for blood transfusions in certain patients who are at high risk of blood loss caused by certain types of surgeries. It may also be used for other conditions as determined by your doctor.

Epoetin Alfa is a synthetic erythropoietin analog. It works by stimulating the bone marrow to produce more red blood cells.

Do NOT use Epoetin Alfa if:

• you are allergic to any ingredient in Epoetin Alfa, including if you have had a severe allergic reaction (eg, rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness) to Epoetin Alfa


• you have uncontrolled high blood pressure


• you have developed a certain type of anemia called pure red cell aplasia (PRCA) after receiving a previous dose of Epoetin Alfa or other erythropoietin protein medicines (eg, darbepoetin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Epoetin Alfa:

Some medical conditions may interact with Epoetin Alfa. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of cancer, seizures, kidney problems (eg, decreased kidney function, kidney failure), blood problems (eg, sickle cell anemia, porphyria, hemolytic anemia, thalassemia), bleeding or clotting problems, stroke, a heart attack or other heart problems (eg, congestive heart failure, ischemic heart disease), diabetes, or high blood pressure


• if you have blood in your stools; an inflection or recent injury; certain bone problems (eg, osteofibrosis cystica); an inflammatory condition (eg, bowel disease, rheumatoid arthritis); low blood iron, folic acid, or vitamin B₁₂ levels; or high blood aluminum levels


• if you are on hemodialysis, have recently had surgery, or are scheduled to have surgery

Some MEDICINES MAY INTERACT with Epoetin Alfa. However, no specific interactions with Epoetin Alfa are known at this time. Tell your health care provider if you are taking any other medicines.

Ask your health care provider if Epoetin Alfa may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Epoetin Alfa:

Use Epoetin Alfa as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

• Epoetin Alfa comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Epoetin Alfa refilled.


• Epoetin Alfa is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Epoetin Alfa at home, a health care provider will teach you how to use it. Be sure you understand how to use Epoetin Alfa. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.


• When drawing up a dose into a syringe, be sure to follow the procedure demonstrated to you to prevent contamination of the vial, syringe, or medicine. Never touch the rubber stopper of the vial or the needle of the syringe with your fingers.


• Always carefully check that you have drawn up the correct dose before administration.


• Do not shake Epoetin Alfa. Do not use Epoetin Alfa if it has been shaken.


• Do not use Epoetin Alfa if it has been frozen.


• Do not dilute Epoetin Alfa. Do not mix it with other solutions unless your doctor directs you otherwise.


• If you are using a single-dose vial, throw away any medicine left in the vial after you have used your dose. Ask your doctor, pharmacist, or other health care provider if you have questions about whether you are using a single-dose vial.


• Do not use Epoetin Alfa if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.


• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.


• Continue to use Epoetin Alfa even if you feel well. Do not miss any doses.


• If you miss a dose of Epoetin Alfa, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Epoetin Alfa.

Important safety information:

• Epoetin Alfa may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Epoetin Alfa with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• It may take several weeks for Epoetin Alfa to work. Do not stop taking Epoetin Alfa without checking with your doctor.


• Do NOT use more than the recommended dose without checking with your doctor.


• It is important to keep your blood pressure under control while you use Epoetin Alfa. Do not stop taking any of your blood pressure medicines without checking with your doctor. Closely follow your doctor's instructions for diet and blood pressure monitoring.


• Tell your doctor immediately if symptoms of anemia persist or recur, such as increased fatigue/weakness or pale skin color.


• Epoetin Alfa contains albumin, which comes from human blood. There is a very rare risk of getting a viral disease or a central nervous system disease called Creutzfeldt-Jakob disease from products with albumin. No cases of these problems have been found in patients who have used Epoetin Alfa.


• Tell your doctor or dentist that you take Epoetin Alfa before you receive any medical or dental care, emergency care, or surgery.


• Lab tests, including kidney function, blood pressure, iron studies, and hemoglobin levels may be performed while you use Epoetin Alfa. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Epoetin Alfa may have benzyl alcohol in it. Do not use medicine with benzyl alcohol in NEWBORNS or INFANTS. It may cause serious and sometimes fatal nervous system problems and other side effects. Check with your doctor or pharmacist to see if your product has benzyl alcohol in it.


• Epoetin Alfa should be used with extreme caution in CHILDREN younger than 1 month old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Epoetin Alfa while you are pregnant. It is not known if Epoetin Alfa is found in breast milk. If you are or will be breast-feeding while you use Epoetin Alfa, check with your doctor. Discuss any possible risks to your baby. Epoetin Alfa may contain the preservative benzyl alcohol. If you are pregnant or are breast-feeding, use a formulation without this preservative. Discuss any questions or concerns with your doctor or pharmacist.

Possible side effects of Epoetin Alfa:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; headache; joint or bone pain; mild muscle pain; mild pain or redness at the injection site; muscle spasms; nausea; trouble sleeping; vomiting; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); calf or leg pain, redness, tenderness, or swelling; chest, jaw, or left arm pain; confusion; coughing up blood; depression; fainting; fast or irregular heartbeat; fever, chills, or sore throat; muscle pain, weakness, or cramping; new or worsening pale skin color, or tiredness or weakness; numbness of an arm or leg; one-sided weakness; seizures; severe or persistent pain or irritation at the injection site; shortness of breath; sudden, severe headache, dizziness, or vomiting; sudden trouble walking, or loss of balance or coordination; swelling of the fingers, ankles, or legs; swelling or soreness of the mouth or tongue; symptoms of high blood sugar (eg, increased thirst, hunger, or urination; drowsiness; flushing; rapid breathing; fruit-like breath odor); trouble swallowing; vision or speech problems; weight gain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Epoetin Alfa side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include severe or persistent headache or dizziness.

Proper storage of Epoetin Alfa:

Epoetin Alfa is usually handled and stored by a health care provider. If you are using Epoetin Alfa at home, store Epoetin Alfa as directed by your pharmacist or health care provider. Keep Epoetin Alfa, as well as syringes and needles, out of the reach of children and away from pets.

General information:

• If you have any questions about Epoetin Alfa, please talk with your doctor, pharmacist, or other health care provider.


• Epoetin Alfa is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Epoetin Alfa. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Epoetin Alfa resources

• Epoetin Alfa Side Effects (in more detail)
• Epoetin Alfa Use in Pregnancy & Breastfeeding
• Epoetin Alfa Drug Interactions
• Epoetin Alfa Support Group
• 2 Reviews for Epoetin Alfa - Add your own review/rating

• Epoetin Alfa Monograph (AHFS DI)


• epoetin alfa Injection Advanced Consumer (Micromedex) - Includes Dosage Information


• Epogen Prescribing Information (FDA)


• Epogen Consumer Overview


• Procrit Prescribing Information (FDA)


• Procrit Consumer Overview

Compare Epoetin Alfa with other medications

• Anemia
• Anemia Associated with Chronic Renal Failure
• Anemia Prior to Surgery
• Anemia, Chemotherapy Induced
• Anemia, Drug Induced

Exelon

Generic Name: rivastigmine (Oral route)

riv-a-STIG-meen

Commonly used brand name(s)

In the U.S.

• Exelon

Available Dosage Forms:

• Solution


• Capsule

Therapeutic Class: Central Nervous System Agent

Pharmacologic Class: Cholinesterase Inhibitor, Centrally Acting

Uses For Exelon

Rivastigmineis used to treat the symptoms of mild to moderate Alzheimer's disease. Rivastigmine will not cure Alzheimer's disease, and it will not stop the disease from getting worse. However, rivastigmine can improve thinking ability in some patients with Alzheimer's disease.

In Alzheimer's disease, many chemical changes take place in the brain. One of the earliest and biggest changes is that there is less of a chemical called acetylcholine (ACh). ACh helps the brain to work properly. Rivastigmine slows the breakdown of ACh, so it can build up and have a greater effect. However, as Alzheimer's disease gets worse, there will be less and less ACh, so rivastigmine may not work as well.

This medicine is available only with your doctor's prescription.

Before Using Exelon

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of rivastigmine in children with use in other age groups.

Geriatric

Studies on rivastigmine have been done only in middle-aged and older patients. Information on the effects of rivastigmine is based on these patients.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Metoclopramide

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Oxybutynin


• Tolterodine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Asthma (or history of) or


• Blockage in the intestines or stomach, or


• Heart problems, including slow heartbeat or hypotension (low blood pressure), or


• Stomach ulcer (or history of) or


• Urinary tract blockage or difficult urination—Rivastigmine may make these conditions worse


• Epilepsy or history of seizures or


• Diabetes, hormone, or thyroid problems that are poorly controlled—Rivastigmine may cause seizures

Proper Use of Exelon

Take this medicine only as directed by your doctor.Do not take more or less of it, and do not take it more or less often than your doctor ordered. Taking too much may increase the chance of side effects, while taking too little may not improve your condition.

Rivastigmine is best taken with food.

Rivastigmine seems to work best when it is taken at regularly spaced times, usually two times a day, in the morning and evening.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (capsules):
  
  • For treatment of Alzheimer's disease:
    
    • Adults—To start, 1.5 milligrams (mg) twice a day. Your doctor may increase your dose gradually if you are doing well on this medicine. However, the dose is usually not more than 6 mg twice a day.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Exelon

It is very important that your doctor check your progress at regular visits.

Tell your doctor if your symptoms get worse, or if you notice any new symptoms.

Before you have any kind of surgery, dental treatment, or emergency treatment, tell the doctor medical doctor or dentist in charge that you are taking this medicine. Taking rivastigmine together with medicines that are sometimes used during surgery or dental or emergency treatments may increase the effects of these medicines.

Rivastigmine may cause some people to become dizzy, clumsy, or unsteady. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.

Rivastigmine causes a large number of patients to have problems with their stomachs and intestines. Tell your doctor about any nausea, vomiting, stomach pain or loss of appetite.

Do not stop taking this medicine or decrease your dose without first checking with your doctor. Stopping this medicine suddenly or decreasing the dose by a large amount may cause mental or behavior changes.

If you think you or someone else may have taken an overdose of rivastigmine, get emergency help at once. Taking an overdose of rivastigmine may lead to convulsions (seizures) or shock. Some signs of shock are large pupils, irregular breathing, and fast weak pulse. Other signs of an overdose are severe nausea and vomiting, increasing muscle weakness, greatly increased sweating, and greatly increased watering of the mouth.

Exelon Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common

• Diarrhea


• indigestion


• loss of appetite


• loss of strength


• nausea and vomiting


• weight loss

Less common

• High blood pressure


• fainting

Rare

• Aggression


• convulsions (seizures)


• trembling and shaking of hands and fingers


• trouble in urinating

Symptoms of overdose

• Seizures


• fast weak pulse


• greatly increased sweating


• greatly increased watering of mouth


• irregular breathing


• increasing muscle weakness


• large pupils


• low blood pressure


• nausea


• slow heartbeat


• vomiting (severe)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Abdominal or stomach pain or cramping


• bloated full feeling


• confusion


• constipation


• mental depression


• dizziness


• fatigue


• headache


• seeing, hearing, or feeling things that are not there


• trouble in sleeping

Less common

• General feeling of discomfort or illness


• increased sweating


• runny nose

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Exelon side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Exelon resources

• Exelon Side Effects (in more detail)
• Exelon Use in Pregnancy & Breastfeeding
• Drug Images
• Exelon Drug Interactions
• Exelon Support Group
• 4 Reviews for Exelon - Add your own review/rating

• Exelon Prescribing Information (FDA)


• Exelon Consumer Overview


• Exelon Monograph (AHFS DI)


• Exelon MedFacts Consumer Leaflet (Wolters Kluwer)


• Rivastigmine Prescribing Information (FDA)


• Rivastigmine Professional Patient Advice (Wolters Kluwer)

Compare Exelon with other medications

• Alzheimer's Disease
• Parkinson's Disease